Exploring the Genetic Architecture of Parkinson's Disease in a Southern Spanish Population

Parkinson's disease (PD), the second most frequent neurodegenerative disease, fits within the wide range of complex polygenic disorders influenced by both genetic and environmental factors. In fact, just around 10% of PD cases are familial, caused by monogenic forms which sometimes exhibit incomplete penetrance. The vast majority of PD cases are sporadic and often present with varied clinical presentations. Therefore, here is when we thought about PD as a single clinical and pathological entity.